We aimed tFinally, we were able to examine the influence of chronotype on the association between chronoactivity and CVD incidence.The study also has some limitations.Although having this information may lead to a better understanding of the observed association, according to the latest WHO report on physical activity, there is no effect difference between leisure of work-related activity on health.Fourth, accelerometer was only collected for seven days at baseline, and therefore does not take into account possible changes of physical activity timing during follow-up.Unfortunately, since these variables were collected several years before the accelerometer measurement period, we were not able to perform mediation analyses to sort this out.Therefore, they could lie in the causal pathway of the associations.Besides, given the observational nature of the study, we cannot rule out that residual confounding plays a role in our observations and we were not able to examine the causal relationship of this association.It is important to keep this in mind when interpreting the results from this study, especially those from the second adjustment model.Despite these limitations, this study adds to the rather unexplored field of research by its strengths [and](http://webbuild.rikosoft.cal.pl
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